Drug-Induced Nutrient Depletions

Drug-Induced Nutrient Depletions

Female hormones These deplete the following:

Estrogen replacement therapyVitamin B6, magnesium
Oral contraceptivesVitamins B1, B2, B3, B6, B12, C, folic acid, magnesium, selenium, zinc, tyrosine

Blood pressure regulators These deplete the following:

HydralazineVitamin B6, Coenzyme Q10,
Loop diureticsCalcium, magnesium, potassium, sodium, zinc, vitamins B1, B6, vitamin C
Thiazide diureticsMagnesium, phosphorus, potassium, sodium, zinc, Coenzyme Q10
Potassium-sparing diureticsFolic acid, calcium, zinc
Blood pressure regulatorsZinc

Cholesterol-lowering drugs These deplete the following:

HydromymethylglutarylCoenzyme Q10, coenzyme A reductase inhibitors (statins)
Bile acid sequestrantsVitamins A, D, E, K, B12, beta-carotene, folic acid, calcium, iron, magnesium
Gemfibrozilphosphorus, zinc, fat (“fibrates” deplete vitamin E, Vitamin B12, copper, zinc) Coenzyme Q10, vitamin E

Anticonvulsants These deplete the following:

Phenobarbital and barbituratesVitamin D and K, biotin, folic acid, calcium
PhenytoinVitamin D, Vitamin K, folic acid, vitamins B1 and B12, biotin, calcium
CarbamazepineVitamin D, folic acid, biotin
PrimidoneBiotin, folic acid, vitamins D and K
Valproic acidFolic acid, carnitine

Anti-inflammatory drugs These deplete the following:

CorticosteroidsVitamins A, C, D, B12, folic acid, calcium, chromium, magnesium, potassium selenium, zinc
Gout medicationsBeta-carotene, vitamin B12, calcium, sodium, potassium, phosphorus
SulfasalazineFolic acid
IndomethacinFolic acid, iron
Other nonsteroidal anti inflammatory drugsFolic acid

Antibiotics Anti-diabetic drugs These deplete the following:

Antibiotics (General)Acidophilus and Bifidus, all B vitamins, vitamin K
Tetracycline antibioticsCalcium, magnesium, iron
Tuberculosis drugsVitamin B3, vitamin B6, vitamin D
NeomycinBeta-carotene, calcium, magnesium, iron, potassium, vitamin A, vitamin B12
TrimethoprimBiotin, folic acid, inositol, B vitamins, vitamin K
SulfonylureasCoenzyme Q10, vitamin E
BiguanidesCoenzyme Q10, vitamin B12, folic acid

Ulcer medications These deplete the following:

H2-receptor antagonistsVitamin B12, folic acid, vitamin D, calcium, iron, zinc (protein)*
Proton pump inhibitorsVitamin B12 (protein)*

Other categories and/or commonly prescribed drugs These deplete the following:

DigoxinCalcium, magnesium, phosphorus
Beta blockersCoenzyme Q10, melatonin
Tricyclic antidepressantsCoenzyme Q10, vitamin B2
PhenothiazinesCoenzyme Q10, vitamin B2, melatonin
Potassium chloride supplementationVitamin B12
Chemotherapeutic drugsMost nutrients
TheophyllineVitamin B6
AnticoagulantsVitamin K
Reverse transcriptase inhibitorsCopper, zinc, vitamin B12, carnitine

Over-the-counter drugs These deplete the following:

AspirinVitamin C, folic acid, iron, potassium
NSAIDsFolic acid
Laxatives-mineral oilVitamins A, D, E, K, beta carotene
Magnesium and aluminum antacidsCalcium, phosphate, folic acid, (protein)*
Sodium bicarbonateFolic acid, magnesium, potassium, (protein)*
Ulcer medicationsVitamin B12, folic acid, vitamin D, zinc

*Problems with the digestion of proteins with use of these drugs have not been documented by scientific studies. However, it is well known that stomach acid is required for proper protein digestion. Therefore, drugs that either neutralize stomach acid or suppress the production of stomach acid are likely to have a negative effect on protein digestion. The passing of undigested protein from the stomach into the small intestine may also cause health problems in its own right.

— From Drug Nutrient Depletions, Ross Pelton, R.Ph., Ph.D. and James B. LaValle, R.Ph.