Fructose

Fructose has a very unique metabolic pathway that results in the formation of uric acid as it is processed.  Research shows levels above 5.5 directly contribute to gout, hypertension, obesity, kidney disease.  Uric acid has both an antioxidant and pro-oxidant nature, so levels too low leave cells exposed to oxidative stress, but levels above 5.5 increase oxidative stress.