The Thyroid and Natural Progesterone Some key points regarding the thyroid gland and the use of natural progesterone cream: Estrogen blocks the release of hormones from the thyroid gland, and natural progesterone facilitates the release. Estrogen excess or progesterone deficiency tends to cause enlargement of the thyroid gland, in association with a hypothyroid state. The use of natural progesterone cream can help re-establish this balance. Calcium and magnesium are typically deficient in hypothyroidism. An excellent, highly bio-available source of both minerals is coral minerals. For men (as well as women), [...]